Journal article
Changes in cortical N-methyl-d-aspartate receptors and post-synaptic density protein 95 in schizophrenia, mood disorders and suicide
B Dean, AS Gibbons, S Boer, A Uezato, J Meador-Woodruff, E Scarr, RE McCullumsmith
Australian and New Zealand Journal of Psychiatry | Published : 2016
Abstract
Objectives: In humans, depending on dose, blocking the N-methyl-d-aspartate receptor (NMDAR) with ketamine can cause psychomimetic or antidepressant effects. The overall outcome for drugs such as ketamine depends on dose and the number of its available binding sites in the central nervous system, and to understand something of the latter variable we measure NMDAR in the frontal pole, dorsolateral prefrontal, anterior cingulate and parietal cortices from people with schizophrenia, bipolar disorder, major depressive disorders and age/sex matched controls. Method: We measured levels of NMDARs (using [3H]MK-801 binding) and NMDAR sub-unit mRNAs (GRINs: using in situ hybridisation) as well as pos..
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Grants
Awarded by National Institute of Mental Health
Funding Acknowledgements
B.D. is a National Health and Medical Research Council (NHMRC) Senior Research Fellow (APP1002240) and E.S. is an Australian Research Council (ARC) Future Fellow (FT100100689) and was the Royce Abbey Postdoctoral Fellow (Australian Rotary). This work was supported in part by NHMRC project grant (APP628699), the Victorian Government's Operational Infrastructure Support, the Andrew and Claire Heenan Ride for Ben and the Rebecca Cooper Medical Research Foundation. The Victorian Brain Bank Network is supported by the Florey Institute for Neuroscience and Mental Health, the Alfred Hospital, the Victorian Forensic Institute of Medicine, the University of Melbourne and funded by Australia's National Health & Medical Research Council, Helen Macpherson Smith Trust, Parkinson's Victoria and Perpetual Philanthropic Services.